Platelets and Thrombopoiesis
نویسندگان
چکیده
1Department of Biochemistry and Molecular & Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2Intensive Care Unit, Xinjiang Traditional Chinese Medicine Hospital, Xinjiang Medical University, Xinjiang, China; 3Jiangsu Institute of Hematology, China Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China; 4Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China; and 5Department of Biology, University of Memphis, Memphis, TN
منابع مشابه
Regular Article PLATELETS AND THROMBOPOIESIS Influenza virus H1N1 activates platelets through FcgRIIA signaling and thrombin generation
• In influenza-immune subjects, H1N1 influenza virus–containing immune complexes can activate platelets through FcgRIIA. • H1N1 can also activate platelets through thrombin, independently of FcgRIIA, pointing to a role of coagulation in influenza infection. Platelets play crucial functions in hemostasis and the prevention of bleeding. During H1N1 influenza A virus infection, platelets display a...
متن کاملIncreased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients.
BACKGROUND Thrombocytopenia is a common finding during viral hemorrhagic fever, which includes hemorrhagic fever with renal syndrome (HFRS). The 2 main causes for thrombocytopenia are impaired thrombopoiesis and/or increased peripheral destruction of platelets. In addition, there is an increased intravascular coagulation risk during HFRS, which could be due to platelet activation. METHODS Thr...
متن کاملPLATELETS AND THROMBOPOIESIS Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets
1Department of Vascular Medicine, University Clinic, University of Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Würzburg, Germany; 2Inserm UMR-S949, Université de Strasbourg, Etablissement Français du Sang (EFS)–Alsace, Strasbourg, France; and 3Biotec Research and Information Centre (BRIC), Biomedical Institute, University of Copenhagen, Copenhagen, Denmark
متن کاملHistorical review: megakaryopoiesis and thrombopoiesis.
The study of thrombopoiesis has evolved greatly since an era when platelets were termed "the dust of the blood," only about 100 years ago. During this time megakaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenitor cells were functionally defined and then purified; and the primary regulator of the process, thrombopoietin, was cloned and characteriz...
متن کاملRegular Article PLATELETS AND THROMBOPOIESIS Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex–mediated inflammation in mice
INSERM Unit 1148, University Paris Diderot, Paris, France; Laboratory for Vascular Translational Science, Sorbonne Paris Cité, Paris, France; Department of Dermatology, University Hospital of Münster, Münster, Germany; Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany; and Department of Vascular Medicine, University Hospital and Rudolf Virchow Center...
متن کاملDifferential Diagnosis of Thrombocytopenia in Hematopoietic Stem Cell Transplant Patients
Thrombocytopenia has remained a major concern in post-haematopoietic stem cell transplant patients. It is a strong negative indicator for survival and is often seen in patients with advanced acute and chronic Graft versus host disease (GVHD). The pathogenesis of thrombocytopenia varies from impaired thrombopoiesis to increased turnover of platelets. The dose of CD34+ cells and that of megakaryo...
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